This paper discusses the theoretical basis, mechanism and clinical application of the theory of " time to subside six-meridian diseases" in Treatise on Cold Pathogenic Diseases. From the correspondence between nature and human, it explains that " time to subside six-meridian diseases refers to the possible relief of a certain period of time. From ancient documents such as Shiji Lu Shu, we can understand the natural characteristics of different time periods, which is helpful for us to better grasp the time of six-meridian in Treatise on Cold Pathogenic Diseases. Under the guidance of the theory of " correspondence between nature and human ", it can be known that the physiological function of human body also has a strict time rhythm, and the human body"s response to drugs in different time periods is also very different. In the " time to subside six-meridian diseases " time range of syndrome differentiation treatment, medicine power with the help of time, can receive unexpected success, get twice the result with half the effort.